Résumés de recherche sur la COVID-19 par Essential Evidence Plus (EE+)

Résumés de recherche sur la COVID-19 par Essential Evidence Plus (EE+)

Alors que la pandémie de COVID-19 continue d’évoluer, l’équipe de Joule travaille en étroite collaboration avec le Dr Mark Ebell, rédacteur en chef d’EE+ et avec l’équipe de la maison d’édition Wiley pour transmettre aux médecins les résumés de recherche les plus récents.

Les personnes abonnées à POEMs* recevront des résumés de recherche liés à la COVID-19 la plupart des fins de semaine et certains jours en semaine. Vous pouvez voir ces mises à jour ci-dessous, vous abonner pour recevoir des résumés de recherche POEMs quotidiens, consulter les archives de POEMs (connexion au compte amc.ca requise) pour commenter ces résumés ou obtenir des crédits de DPC, ou consulter la page Web d’Essential Evidence Plus consacrée à la COVID-19.

Essential Evidence Plus (EE+) offre un accès gratuit à des renseignements pertinents sur la COVID-19 pour aider les médecins à soigner les patients du monde entier. Les sujets liés aux Infections au Coronavirus SRAS-CoV-2 (COVID-19) sont mis à jour lorsqu’il y a de nouveaux développements.

Question clinique

Is risk of COVID-19-related mortality or morbidity higher in patients receiving biologic agents? Is convalescent plasma safe?

L’Essentiel

Patients taking biologic agents not at greater risk of poor outcomes. Patients receiving convalescent plasma have few transfusion-related serious adverse events. 4

Référence

Haberman R, Axelrad J, Chen A, et al. Covid-19 in Immune-Mediated Inflammatory Diseases - Case Series from New York [published online ahead of print, 2020 Apr 29]. N Engl J Med. 2020;NEJMc2009567. doi:10.1056/NEJMc2009567

Auteur(s)

Mark H. Ebell, MD, MS

Question clinique

Do stay-at-home orders or social distancing policies reduce the spread of COVID-19?

L’Essentiel

Retrospective data suggest that the implementation of stay-at-home and social distancing policies in US counties slowed the spread of COVID-19. 4

Référence

Lyu W, Wehby GL. Comparison of estimated rates of coronavirus disease 2019 (covid-19) in border counties in Iowa without a stay-at-home order and border counties in Illinois with a stay-at-home order. JAMA Netw Open. Published online May 1, 2020. doi:10.1001/jamanetworkopen.2020.11102.

Auteur(s)

John Hickner, MD, MS

Question clinique

Can hydroxychloroquine, chloroquine, or azithromycin improve outcomes for patients with SARS-CoV-2 infection?

L’Essentiel

Hydroxychloroquine (HCQ), chloroquine, and azithromycin, used alone or in combination, do not reduce mortality in patients with COVID-19 and increase the risk of serious cardiac-related adverse events. 4

Référence

Rosenberg ES, Dufort EM, Udo T, et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State. JAMA. Published online May 11, 2020. doi:10.1001/jama.2020.8630

Auteur(s)

Henry C. Barry, MD, MS

Question clinique

What is the rate of COVID-19 among asymptomatic pregnant women? Can homemade face masks prevent transmission of the virus?

L’Essentiel

The high rate of asymptomatic carriage of COVID-19 among pregnant women admitted to hospitals in New York suggests that COVID-19 spread will be difficult to contain with medical isolation, quarantine, and contact tracing only. There is equivocal evidence of effectiveness of face masks for preventing transmission. 4

Référence

Sutton D, Fuchs K, D'Alton M, Goffman D. Universal screening for SARS-CoV-2 in women admitted for delivery [letter]. N Engl J Med. Published online April 13, 2020. doi:10.1056/NEJMc2009316.

Auteur(s)

John Hickner, MD, MS

Question clinique

What was the outcome for patients hospitalized with COVID-19 in New York City in March/April 2020? Can a cluster of COVID-19 cases be linked to a small restaurant in China, despite table distancing?

L’Essentiel

COVID-19 infection had a high mortality rate in patients who were hospitalized in New York City during March/April 2020, especially in those who required mechanical ventilation. Investigators uncover possible transmission of COVID-19 in a restaurant in China despite a distance of 1 meter (3 feet) among tables. 4

Référence

Richardson S, Hirsch JS, Narasimhan M, et al. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA. Published online April 22, 2020. doi:10.1001/jama.2020.6775.

Auteur(s)

John Hickner, MD, MS

Question clinique

Do patients who take antihypertension medications have an increased risk of developing COVID-19?

L’Essentiel

Retrospective data from these 2 US studies show that 5 common classes of antihypertensive classes were not associated with increased risk of contracting COVID-19 or increased severity of illness. 4

Référence

Mehta N, Kalra A, Nowacki AS, et al. Association of use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with testing positive for coronavirus disease 2019 (COVID-19). JAMA Cardiology. Published online May 5, 2020. doi: 10.1001/jamacardio.2020.1855. Reynolds HR, Adhikari S, Pulgarin C, et al. Renin-angiotensin-aldosterone system inhibitors and risk of Covid-19. N Engl J Med. Published online May 1, 2020; updated May 6, 2020. doi: 10.1056/NEJMoa2008975.

Auteur(s)

Henry C. Barry, MD, MS

Question clinique

Does SARS-CoV-2 infection increase the risk of stroke in people younger than 50 years? Can remdesivir improve recovery time in people with SARS-CoV-2 infection?

L’Essentiel

This very small case series indicates that COVID-19 may increase the rate of stroke in people younger than 50 years. Preliminary data from this large US trial shows shorter recovery tiime in people who received remdesivir 4

Référence

Oxley TJ, Mocco J, Majidi S, et al. Large-vessel stroke as a presenting feature of Covid-19 in the young. N Engl J Med. Published online April 28, 2020. doi: 10.1056/NEJMc2009787.

Auteur(s)

Mark H. Ebell, MD, MS

 

 

*Avertissement : L’abréviation « POEMs » vient de « Patient-Oriented Evidence that Matters » (données probantes et pertinentes axées sur les patients). Les POEMs sont publiés par John Wiley and Sons, Inc. et distribués par Joule comme service aux membres de l’AMC. Tous les éléments du contenu sont présentés à titre informatif et éducatif seulement et ne remplacent en rien les conseils d’un médecin. Joule se dégage de toute responsabilité civile ou légale découlant de toute erreur ou omission, ou de l’utilisation de tout renseignement contenu aux présentes.